Analytical Chemist

Analytical Chemist Boston, MA $35-40/hr The Analytical Chemist will join the Mass Spectrometry group. In this role, you will be responsible for the end-to-end development, validation, and execution of LC-MS methods across a diverse range of modalities—from primary metabolites and small molecules to complex peptides and intact proteins. Analytical Chemist Responsibilities: Method Development: Design and optimize robust LC-MS/MS methods for the quantification and characterization of small molecules, specialized metabolites, peptides, and proteins. Instrumentation: Operate, maintain, and troubleshoot state-of-the-art mass spectrometers, specifically Thermo Orbitrap (Exploris/Lumos) and Triple Quadrupole (TSQ) systems. Data Processing: Utilize advanced software (e.g., TraceFinder, Compound Discoverer, Proteome Discoverer, or Skyline) to process complex datasets and deliver actionable insights to project teams. Independent Execution: Manage multiple projects simultaneously, from initial experimental design and sample preparation to final data reporting, with minimal supervision. Cross-Functional Collaboration: Partner with metabolic engineers, synthetic biologists, and automation engineers to integrate analytical assays into the high-throughput pipelines. Analytical Chemist Requirements: Master’s degree in Analytical Chemistry, Biochemistry, or a related field; or a Bachelors degree with 3+ years of relevant industrial experience. Hands-on experience with high-resolution accurate mass (HRAM) and MRM/SRM workflows. Expertise in various chromatography techniques (RPLC, HILIC, Ion Exchange). Familiarity with sample preparation techniques for biological matrices (SPE, SLE, protein precipitation). Strong ability to troubleshoot hardware issues and interpret "messy" biological data. Excellent written and verbal communication skills, with the ability to present complex analytical findings to non-experts. #INDHS